北京生命科技研究院 · 助理研究员

赵婧

zhaoj@blsa.com.cn

以光化学反应与串级质谱技术为核心策略，为脂质精细结构和脂质–蛋白相互作用的表征提供新工具。

  • 质谱
  • 脂质组学
  • 光化学
查看论文 研究方向
抽象艺术：浅蓝与嫩绿的光晕、流动曲线与颗粒构成

研究方向

光化学标记 × 串级质谱：从分子结构到相互作用

脂质精细结构解析

围绕碳碳双键位置、sn-位归属与鞘脂骨架，发展光化学衍生、自由基导向解离等质谱方法，实现异构体的深度分辨。

脂质–蛋白相互作用

以光标记探针捕获瞬时、微弱的脂质–蛋白接触，解析跨膜结构域周围环状脂质的组成偏好与化学计量。

交叉应用方向

面向神经生物学中的脂质信号分子识别，以及植物生物制造中的脂质代谢与工程改造。

教育经历

化学背景，聚焦质谱与光化学

  1. 2018 — 2024

    清华大学 · 化学系

    博士

  2. 2014 — 2018

    兰州大学 · 萃英学院

    化学班 · 学士

论文发表

共 12 篇同行评议论文，其中第一作者及共同第一作者 6 篇

  1. 2026

    Zhao J, Dong X, Wan W, et al.

    Revealing the Hydrophobic Interactions between Annular Lipids and Transmembrane Peptides via Photo-Tagging and Mass Spectrometry.

    J Am Chem Soc, 2026.

  2. 2025

    Chen Z, Gong Y, Chen F, Lee HJ, Qian J, Zhao J, et al.

    Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial–mesenchymal transition and metastasis.

    Cancer Commun, 2025, 45: 245–280.

  3. 2024

    Duan Y#, Leong N#, Zhao J#, et al.

    Structural basis of sphingosine-1-phosphate transport via human SPNS2.

    Cell Res, 2024, 34: 177–180.

  4. 2024

    Xiong Y#, Xu Z#, Li X#, Wang Y#, Zhao J#, et al.

    Identification of oleic acid as an endogenous ligand of GPR3.

    Cell Res, 2024, 34: 232–244.

  5. 2023

    Zhao J, Qiao L, Xia Y.

    In-depth characterization of sphingoid bases via radical-directed dissociation tandem mass spectrometry.

    J Am Soc Mass Spectrom, 2023, 34(10): 2394–2402.

  6. 2022

    Li H, Zhao J, Cao W, et al.

    Site-specific photochemical reaction for improved C=C location analysis of unsaturated lipids by ultraviolet photodissociation.

    Research, 2022, 9783602.

  7. 2022

    Zhang W, Jian R, Zhao J, et al.

    Deep-lipidotyping by mass spectrometry: recent technical advances and applications.

    J Lipid Res, 2022, 63: 100219.

  8. 2022

    Wang N, He X, Zhao J, et al.

    Structural basis of leukotriene B4 receptor 1 activation.

    Nat Commun, 2022, 13: 1156.

  9. 2022

    Zhang D, Lin Q, Xia T, Zhao J, et al.

    LipidOA: a machine-learning and prior-knowledge-based tool for structural annotation of glycerophospholipids.

    Anal Chem, 2022, 94(48): 16759–16767.

  10. 2021

    Zhao J, Fang M, Xia Y.

    A liquid chromatography–mass spectrometry workflow for in-depth quantitation of fatty acid double bond location isomers.

    J Lipid Res, 2021, 62: 100110.

  11. 2020

    Zhao J, Xie X, Lin Q, et al.

    Next-generation Paternò–Büchi reagents for lipid analysis by mass spectrometry.

    Anal Chem, 2020, 92(19): 13470–13477.

  12. 2020

    Xie X, Zhao J, Lin M, et al.

    Profiling of cholesteryl esters by coupling charge-tagging Paternò–Büchi reaction and liquid chromatography–mass spectrometry.

    Anal Chem, 2020, 92(12): 8487–8496.

# 共同第一作者

其他

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